產(chǎn)品編號(hào) yb-1416R
英文名稱 Anti-AHR抗體
中文名稱 芳香烴受體抗體
別    名 Ah receptor; AHR; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN.
Anti-AHR抗體 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aryl Hydrocarbon Receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.

Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.

Subcellular Location:
Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Tissue Specificity:
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain. 
Contains 1 PAC (PAS-associated C-terminal) domain. 
Contains 2 PAS (PER-ARNT-SIM) domains.

是一種配體激活轉(zhuǎn)錄因子,可介導(dǎo)多環(huán)芳烴類化合物的毒性（包括致癌性）反應(yīng),還參與一些重要的生物學(xué)過程,如信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞分化、細(xì)胞凋亡等。人體的肺、肝、腎、胎盤、腭扁桃體、B淋巴細(xì)胞等各種組織和細(xì)胞中都存在AHR。AHR對(duì)生長發(fā)育和生理功能等具有調(diào)控作用,在一些癌癥（乳腺癌和卵巢癌等）發(fā)生發(fā)展中起促進(jìn)作用。