產(chǎn)品編號 bs-1576R
英文名稱 Anti-ALR抗體
中文名稱 肝再生增強(qiáng)因子抗體
別    名 Augmenter of Liver Regeneration; ERV1 homolog; GFER; Growth factor erv1 like; hERV; HERV1; HPO.
 Anti-ALR抗體  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ALR C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
產(chǎn)品介紹 background:
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). Also known as: augmenter of liver regeneration; ERV1 homolog; GFER; Growth factor erv1 like; hERV; HERV1; HPO.

Function:
Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. 
Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Subcellular Location:
Mitochondrion intermembrane space and Cytoplasm. Secreted.

Tissue Specificity:
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.

DISEASE:
Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD) [MIM:613076]; also called combined mitochondrial complex deficiency.

Similarity:
Contains 1 ERV/ALR sulfhydryl oxidase domain.

 是近年來發(fā)現(xiàn)的一種促肝細(xì)胞再生的細(xì)胞因子。ALR的生物學(xué)作用主要表現(xiàn)在直接刺激肝細(xì)胞增殖和再生、對肝臟的保護(hù)作用、參與組織器官的形成與發(fā)育、免疫調(diào)控作用以及促肝癌細(xì)胞增殖等效應(yīng)。s雖然肝再生增強(qiáng)因子有著重要生物學(xué)作用,但ALR究竟如何發(fā)揮生物學(xué)的調(diào)節(jié)機(jī)制，目前還不清楚