產(chǎn)品編號 yb-3922R
英文名稱 Anti-ADCY5抗體
中文名稱 腺苷酸環(huán)化酶5抗體
別    名 AC 5; AC5; ADCY 5; Adcy5; ADCY5_HUMAN; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5; ATP pyrophosphate lyase 5; ATP pyrophosphate-lyase 5.
Anti-ADCY5抗體  
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADCY5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Subunit:
Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2. Interacts with RAF1.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell projection, cilium.

Post-translational modifications:
Phosphorylated by RAF1.

DISEASE:
Defects in ADCY5 are the cause of dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]. A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

 Database links:
UniProtKB/Swiss-Prot: O95622.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.