產(chǎn)品編號(hào) yb-6515R
英文名稱 Anti-ABC2抗體
中文名稱 乳腺癌增強(qiáng)蛋白2抗體
別    名 ABC 2; ABC2; ABC-2; Amplified in breast cancer gene 2 protein; Chromosome 17 open reading; chromosome 17 open reading frame 71; Protein smg 8 homolog; protein SMG8; SMG8; SMG8 protein; SMG8_HUMAN.
Anti-ABC2抗體   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  腫瘤細(xì)胞生物標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 110kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABC2/C17orf71 (744-790aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
C17orf71 belongs to the UPF0487 family. There are 3 isoforms produced by alternative splicing.Positive control;Human Anaplastic Thyroid Carcinoma, Human Breast Carcinoma.

Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. 

Subunit:
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.

Subcellular Location:
Phosphorylated by SMG1

Post-translational modifications:
Phosphorylated by SMG1. 

Similarity:
Belongs to the SMG8 family. 

Database links:

UniProtKB/Swiss-Prot: Q8ND04.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.