產(chǎn)品編號(hào) yb-7959R
英文名稱 Anti-AMIGO3抗體
中文名稱 粘附分子IgG樣結(jié)構(gòu)域蛋白3抗體
別    名 Adhesion molecule with Ig like domain 3; ALI3; Alivin 3; AMIGO 3; Amphoterin induced gene and ORF 3; Amphoterin induced protein 3 precursor.AMGO3_HUMAN
規(guī)格價(jià)格 0.2ml/1280元 購(gòu)買    
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Pig, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AMIGO3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-AMIGO3抗體
PubMed PubMed
產(chǎn)品介紹 background:
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction.

Function:
AMIGO3 may mediate heterophilic cell-cell interaction and may also contribute to signal transduction through its intracellular domain.

Subunit:
Binds AMIGO1 or AMIGO2 (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein

Similarity:
Belongs to the immunoglobulin superfamily. AMIGO family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.