產(chǎn)品編號(hào) yb-6006R
英文名稱 Anti-FBXO31抗體
中文名稱 F-box蛋白家族FBXO31抗體
別    名 F box only protein 31; FBX14; FBX31; FBXO14; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor; FBX31_HUMAN.
 Anti-FBXO31抗體  
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXO31 (170-225aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
產(chǎn)品介紹 background:
FBXO31 belongs to the F-box protein family. Such proteins are characterized by an F-box motif of approximay 40 residues. F-box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains. There are two different isoforms.

Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Tissue Specificity:
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
 
Post-translational modifications:
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.